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Althoff/Schulte/2016a: Towards diagnostic application of non-coding RNAs in neuroblastoma

Bibtype Article
Bibkey Althoff/Schulte/2016a
Author Althoff, Kristina and Schulte, Johannes and Schramm, Alexander
Title Towards diagnostic application of non-coding RNAs in neuroblastoma
Journal Expert Review of Molecular Diagnostics
Volume 16
Number 12
Pages 1307-1313
Abstract Neuroblastoma is a solid cancer of childhood, which is devastating upon recurrence. Markers for minimal residual disease and early detection of relapse are eagerly awaited to improve the outcome of affected patients. Several miRNAs have been identified as key regulators of neuroblastoma pathogenesis. Areas covered: Here, we focus on miRNAs that have been linked to MYCN, a prominent oncogenic driver, and we review the hitherto known interactions between miRNAs and other important players in neuroblastoma. Expert commentary: Existing diagnostic miRNA signatures remain to be established in clinical settings. Moreover, inhibition of individual oncogenic miRNAs or enhancement of tumor suppressive miRNA function could represent a new therapeutic approach in cancer treatment, including NB.
Month Dec
Year 2016
Projekt sfb876-c1
Url http://www.tandfonline.com/doi/abs/10.1080/14737159.2016.1256207
 
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