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Shpacovitch/2012b: Interferons, Serine Proteases and Protease-activated receptors: Enemies or Partners?

Bibtype Inbook
Bibkey Shpacovitch/2012b
Author Shpacovitch, Victoria
Editor Joe H. Thomas, Adrian Roberts
Title Interferons, Serine Proteases and Protease-activated receptors: Enemies or Partners?
Booktitle Interferons: Characterirization, Mechanism of Action and Clinical Application
Pages 95-105
Publisher Nova Publishers
Abstract Interferons (IFNs) were discovered as a natural defense system against viral pathogens. However, in the present time, the role of interferons in human body is being reconsidered. This family of cytokines is now believed to regulate a wide range of activities including cell differentiation, immune responses, anti-microbial and anti-tumor activities. Serine proteases and protease-activated receptors (PARs) are also known to be involved in immune responses, anti-viral and anti-tumor defense. Altogether, these facts arise an intriguing question whether serine proteases, activated PARs and interferons may cooperate in the regulation of immune response and other functions. Whether the interactions between serine proteases, their receptors and interferons occur only locally or also take place at the level of whole organism needs further investigation. Understanding of the mechanisms of interactions between serine proteases, serine protease receptors and interferons may help to improve the quality of already existing interferon-based therapies and to develop novel therapeutic approaches.
Year 2012
Projekt SFB876-B2
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