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Gurevich/etal/2011a: Analytical Features of Particle Counting Sensor based on Plasmon assisted Microscopy of Nano Objects

Bibtype Article
Bibkey Gurevich/etal/2011a
Author Gurevich, Evgeny L. and Temchura, Vladimir and Überla, Klaus and Zybin, Alexander
Title Analytical Features of Particle Counting Sensor based on Plasmon assisted Microscopy of Nano Objects
Journal Sensors and Actuators B: Chemical
Volume B 160
Number 1
Pages 1210 - 1215
Abstract We present a new analytical method for concentration measurements of nano objects of different nature
such as polystyrene nanoparticles or viruses. The method is based on counting single particles of interest
bound to a functionalized sensor surface. The counting rate was used for concentration measurements.
For polystyrene particles, the counting rate was found to be in good agreement with the theoretically
predicted one. Binding of human immunodeficiency virus (HIV) virus-like particles (VLPs) to the sensor
surface functionalized with antibodies was observed. The concentration of HIV–VLP was estimated by
means of well-characterized solutions of artificial nanoparticles as a reference material. The results are
in a good agreement with standard enzyme-linked immunosorbent assay (ELISA) analysis. Factors are
discussed which determine the detection power of the method.
Month 09
Year 2011
Projekt SFB876-B2
Url http://www.sciencedirect.com/science/article/pii/S0925400511008525
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