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Alexa/etal/2006a: Improved scoring of functional groups from gene expression data by decorrelating GO graph structure

Bibtype Article
Bibkey Alexa/etal/2006a
Author Adrian Alexa and Jörg Rahnenführer and Thomas Lengauer
Title Improved scoring of functional groups from gene expression data by decorrelating GO graph structure
Journal Bioinformatics
Volume 22
Number 13
Pages 1600--1607
Institution Max-Planck-Institute for Informatics Stuhlsatzenhausweg 85, D-66123 Saarbrücken, Germany. alexa@mpi-sb.mpg.de
Abstract MOTIVATION: The result of a typical microarray experiment is a long list of genes with corresponding expression measurements. This list is only the starting point for a meaningful biological interpretation. Modern methods identify relevant biological processes or functions from gene expression data by scoring the statistical significance of predefined functional gene groups, e.g. based on Gene Ontology (GO). We develop methods that increase the explanatory power of this approach by integrating knowledge about relationships between the GO terms into the calculation of the statistical significance. RESULTS: We present two novel algorithms that improve GO group scoring using the underlying GO graph topology. The algorithms are evaluated on real and simulated gene expression data. We show that both methods eliminate local dependencies between GO terms and point to relevant areas in the GO graph that remain undetected with state-of-the-art algorithms for scoring functional terms. A simulation study demonstrates that the new methods exhibit a higher level of detecting relevant biological terms than competing methods.
Month Jul
Year 2006
Projekt SFB876-A3
Url http://dx.doi.org/10.1093/bioinformatics/btl140
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